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xhoHordhac Dhamaystiran ee 5-ALA/ICG Farsamada Sawirka Fluorescence Molecular ee Endoscopy Medical
Sawir-qaadista molecular fluorescence imaging waa tignoolajiyada kacaanka ee goobta endoscopy-ga caafimaadka sannadihii la soo dhaafay, taas oo ku guulaysata wakhtiga dhabta ah iyo ogaanshaha muuqaalka saxda ah iyo daawaynta iyada oo loo marayo xidhid gaar ah oo calaamado fluorescent gaar ah (sida 5-ALA, ICG) ee unugyada buka. Kuwa soo socdaa waxay bixiyaan falanqayn dhamaystiran oo ku saabsan mabaadi'da farsamada, codsiyada kiliinikada, faa'iidooyinka isbarbardhigga, alaabta wakiillada, iyo isbeddellada mustaqbalka.
1. Mabaadi'da farsamada
(1) Habka ficilka calaamadaha fluorescent
(2) Halabuurka habka sawirka
Isha iftiinka xiisaha leh: Mawjada dhaadheer ee gaarka ah ee LED ama laser (sida kicinta iftiinka buluuga ah ee 5-ALA).
Filterka indhaha: wuxuu miiriyaa iftiinka faragelinta wuxuuna qabtaa kaliya calaamadaha iftiinka.
Habaynta sawirka: ku dahaadhan calaamadaha fluorescent oo leh sawirro iftiin cad (sida muujinta wakhtiga-dhabta ah ee nidaamka PINPOINT).
2. Faa'iidooyinka asaasiga ah ( vs dhaqameedka iftiinka cad ee endoscopy)
3. Xaalado codsi caafimaad
(1) 5-ALA endoscope florescence
Qalliinka neerfaha:
Qalliinka dib-u-soo-celinta Glioma: Calaamadeynta PPIX fluorescence ee xuduudaha burooyinka waxay kordhisaa wadarta heerka is-goynta 20% (haddii loo oggolaado isticmaalka GLIOLAN).
Urology:
O ogaanshaha kansarka kaadiheysta: cystoscopy-ga fluorescent (sida Karl Storz D-LIGHT C) wuxuu yareeyaa heerka soo noqoshada.
(2) ICG fluorescence endoscopy
Qalliinka cagaarshowga:
Qalliinka soo-jaridda kansarka beerka: dib-u-eegidda saxda ah ee haynta ICG meelaha togan (sida Olympus VISERA ELITE II).
Qaliinka Naaska:
biopsy Sentinel lymph node: Baafinta ICG waxay beddeshaa isotopes shucaac ah.
(3) Codsiga wadajirka ah ee habka badan
Fluorescence+NBI: Olympus EVIS X1 waxay isku daraysaa sawirka cidhiidhiga ah iyo ICG fluorescence si loo hagaajiyo heerka ogaanshaha kansarka caloosha.
Fluorescence+ultrasound: Calaamadaynta ICG ee burooyinka ganaca ee uu hago endoscopic ultrasonography (EUS).
4. Matalaya soo saarayaasha iyo alaabta
5. Caqabado farsamo iyo xalal
(1) Digniinta fluorescence attenuation
Dhibaatada: Muddada 5-ALA fluorescence waa gaaban yahay (qiyaastii 6 saacadood).
Xalka:
o Maamulka qalliinka ee dufcadaha (sida dhiigbax badan inta lagu jiro qaliinka kansarka kaadiheysta).
(2) Been togan/ taban been ah
Dhibaato: Caabuqa ama unugyada nabartu waxay khaldami karaan fluorescence.
Xalka:
Falanqaynta dhinacyo badan leh (sida kala soocidda PPIX iyo autofluorescence).
(3) Qiimaha iyo caannimada
Dhibaatada: Qiimaha nidaamyada endoscopic fluorescent waa sarreeya (qiyaastii 2 ilaa 5 milyan yuan).
Jihada horumarka:
Beddelka guriga (sida nidaamka Mindray ME8).
Endoscope fluorescent la tuuri karo (sida Ambu aScope ICE).
6. Isbeddellada Horumarineed ee Mustaqbalka
(1) Baadhitaanka fluorescent cusub: Tumor gaar ah calaamadaynta fluorescent antibody (sida EGFR baadhisyada la beegsaday).
(2) Falanqaynta tirada AI: Qiimaynta otomaatigga ah ee xoojinta fluorescence (sida isticmaalka software ProSense si loo qiimeeyo burada malignant).
(3) Farsamada Nanofluorescence: Calaamadaynta Quantum Dot (QDs) waxay awood u siinaysaa sawir-qaadista isku-dhafka ah ee bartilmaameedyada badan.
(4) Portability: Gacan-ku-haynta florescent (sida loo isticmaalo baadhista cosbitaalada aasaasiga ah).
soo koobid
Tiknoolajiyada sawirka molecular fluorescence waxay bedelaysaa jaantuska ogaanshaha burada iyo daawaynta iyada oo loo marayo "calaamadaynta saxda ah+navigation-waqtiga dhabta ah":
Ogaanshaha: Heerarka ogaanshaha kansarka hore ayaa si aad ah u kordhay, taas oo yaraysay biopsiyada aan loo baahnayn.
Daawaynta: Xadka qaliinka ayaa aad u saxsan, isaga oo yaraynaya khatarta soo noqoshada.
Mustaqbalka: Iyada oo kala duwanaanshaha baaritaanka iyo isdhexgalka AI, waxaa la filayaa inay noqoto qalab caadi ah oo loogu talagalay "pathology intraoperative".