Medical Endoscopy Black Technology (2) Molecular Fluorescence Imaging (monga 5-ALA/ICG)

Chidziwitso Chokwanira cha 5-ALA/ICG Molecular Fluorescence Imaging Technology mu Medical Endoscopy

Kujambula kwa mamolekyulu a fluorescence ndiukadaulo wosinthira pazachipatala m'zaka zaposachedwa, zomwe zimakwaniritsa zenizeni zenizeni komanso zowona zowona ndikuchiza kudzera pakumangirira kwapadera kwa zolembera za fulorosenti (monga 5-ALA, ICG) ku minofu yomwe ili ndi matenda. Zotsatirazi zimapereka kusanthula kwatsatanetsatane kwa mfundo zaumisiri, ntchito zachipatala, zopindulitsa zofananira, zinthu zoyimilira, ndi zomwe zidzachitike m'tsogolo.

1. Mfundo zaukadaulo

(1) Njira yopangira zolembera za fulorosenti

(2) Mapangidwe a kachitidwe ka zithunzi

Gwero la kuwala kosangalatsa: Mafunde enieni a LED kapena laser (monga kuwala kwa buluu kwa 5-ALA).

Zosefera zowonera: zimasefa kuwala kosokoneza ndipo zimangojambula ma siginecha a fluorescence.

Kukonza zithunzi: Kuphimba ma siginecha a fulorosenti okhala ndi zithunzi zoyera (monga chiwonetsero cha nthawi yeniyeni ya PINPOINT).

2. Ubwino wapakati (kuyerekeza ndi endoscopy yoyera yoyera)

3. Zochitika zachipatala zogwiritsira ntchito

(1) 5-ALA fluorescence endoscope

Neurosurgery:

Opaleshoni ya Glioma resection: Kulemba kwa PpIX fluorescence kwa malire a chotupa kumawonjezera kuchuluka kwa kuchotsedwa kwathunthu ndi 20% (ngati kuvomerezedwa kuti agwiritsidwe ntchito ndi GLIOLAN).

Urology:

O Kuzindikira khansa ya chikhodzodzo: fluorescent cystoscopy (monga Karl Storz D-LIGHT C) imachepetsa kubwereza.

(2) ICG fluorescence endoscope

Opaleshoni ya Hepatobiliary:

Opaleshoni yochotsa khansa ya chiwindi: kuchotseratu malo abwino osungira ICG (monga Olympus VISERA ELITE II).

Opaleshoni ya Mabere:

Sentinel lymph node biopsy: Kufufuza kwa ICG kumalowa m'malo mwa isotopu ya radioactive.

(3) Multi modal olowa ntchito

Fluorescence+NBI: Olympus EVIS X1 imaphatikiza kujambula kocheperako ndi ICG fluorescence kuti apititse patsogolo kuchuluka kwa matenda a khansa ya m'mimba.

Fluorescence+ultrasound: Kulemba kwa ICG kwa zotupa zam'mimba motsogozedwa ndi endoscopic ultrasonography (EUS).

4. Kuimira opanga ndi mankhwala

5. Mavuto aukadaulo ndi mayankho

(1) Kuchepetsa chizindikiro cha fluorescence

Vuto: Nthawi ya 5-ALA fluorescence ndi yayifupi (pafupifupi maola 6).

Yankho:

O Kuwongolera m'magulu (monga kuthira kangapo panthawi ya opaleshoni ya khansa ya chikhodzodzo).

(2) Zolakwika zabwino/zabodza

Vuto: Kutupa kapena zipsera za minofu zimatha kulakwitsa fulorosenti.

Yankho:

Kusanthula kosiyanasiyana (monga kusiyanitsa PpIX kuchokera ku autofluorescence).

(3) Mtengo ndi Kutchuka

Vuto: Mtengo wa makina a fulorosenti endoscopic ndi wokwera (pafupifupi 2 mpaka 5 miliyoni yuan).

Njira yolowera:

Kulowetsa m'nyumba (monga Mindray ME8 system).

Endoscope yotayika ya fulorosenti (monga Ambu aScope ICE).

6. Zochitika Zachitukuko Zamtsogolo

(1) Kufufuza kwatsopano kwa fulorosenti:Kulemba zilembo zamtundu wa chotupa (monga ma probe olunjika a EGFR).

(2) Kusanthula kachulukidwe ka AI: Kuwerengera mokha kwa mphamvu ya fluorescence (monga kugwiritsa ntchito pulogalamu ya ProSense kuyesa kuopsa kwa chotupa).

（3）Tekinoloje ya Nanofluorescence:Kulemba madontho a Quantum (QDs) kumathandizira kuyerekeza kwamitundu yambiri.

(4) Kusunthika: Endoscope ya fulorosenti ya m'manja (monga yogwiritsidwa ntchito powunika m'zipatala zoyambirira).

fotokoza mwachidule

Ukadaulo woyerekeza wa mamolekyulu a fluorescence ukusintha mawonekedwe a matenda a chotupa ndi chithandizo kudzera mu "kulemba molondola + zenizeni zenizeni":

Kuzindikira: Kuzindikira kwa khansa yoyambirira kwakula kwambiri, kuchepetsa ma biopsies osafunikira.

Chithandizo: Mphepete mwa opaleshoni ndi yolondola kwambiri, kuchepetsa chiopsezo chobwereza.

Tsogolo: Ndi kusiyanasiyana kwa ma probes ndi kuphatikiza kwa AI, akuyembekezeka kukhala chida chokhazikika cha "intraoperative pathology".