Medical Endoscopy Black Technology (2) Okukuba ebifaananyi mu molekyu (nga 5-ALA/ICG) .

Enyanjula enzijuvu ku tekinologiya wa 5-ALA/ICG Molecular Fluorescence Imaging Technology mu Medical Endoscopy

Molecular fluorescence imaging ye tekinologiya ow’enkyukakyuka mu by’obujjanjabi endoscopy mu myaka egiyise, atuuka ku kuzuula mu kiseera ekituufu era okutuufu okulaba n’okujjanjaba okuyita mu kusiba okwetongodde okw’obubonero obw’enjawulo obw’ekitangaala (nga 5-ALA, ICG) ku bitundu ebirwadde. Wammanga kiwa okwekenneenya okujjuvu okw’emisingi egy’ekikugu, enkozesa y’obujjanjabi, enkizo mu kugeraageranya, ebintu ebikiikirira, n’emitendera egy’omu maaso.

1. Emisingi gy’ebyekikugu

(1) Enkola y’okukola kw’obubonero obutangaavu

(2) Ebitonde by’enkola y’okukuba ebifaananyi

Ensibuko y’ekitangaala eky’okusikirizibwa: LED oba layisi ey’obuwanvu bw’amayengo obw’enjawulo (nga okusikirizibwa kw’ekitangaala kya bbululu ekya 5-ALA).

Optical filter: esengejja ekitangaala ekitaataaganya era ekwata obubonero bwa fluorescence bwokka.

Okukola ebifaananyi: okubikka ku bubonero bwa fluorescent n’ebifaananyi by’ekitangaala ekyeru (nga real-time fusion display of PINPOINT system).

2. Ebirungi ebikulu (vs endoscopy y’ekitangaala ekyeru eky’ennono) .

3. Ensonga z’okukozesa mu bujjanjabi

(1) Endoscope ya 5-ALA ey’okumasamasa

Okulongoosa obusimu:

Okulongoosa okusalako Glioma: Okuwandiika ku nsalo z’ekizimba mu ngeri ya PpIX fluorescence kyongera ku muwendo gwonna ogw’okusalako ebitundu 20% (bwe kiba nga kikkirizibwa okukozesebwa ne GLIOLAN).

Okujjanjaba omusulo:

O Okuzuula kookolo w’ekibumba: okukebera kookolo w’ekibumba (fluorescent cystoscopy) (nga Karl Storz D-LIGHT C) kukendeeza ku muwendo gw’okuddamu.

(2) Endoscope ya ICG ey’okumasamasa

Okulongoosa ekibumba n’omusaayi:

Okulongoosa okusala kookolo w’ekibumba: okusalako obulungi ebitundu ebirina ICG retention positive (nga Olympus VISERA ELITE II).

Okulongoosa Amabeere:

Sentinel lymph node biopsy: Okulondoola ICG kudda mu kifo kya isotope ezikola amasannyalaze.

(3) Okukozesa ebiyungo mu ngeri ez’enjawulo

Fluorescence+NBI: Olympus EVIS X1 egatta ebifaananyi ebifunda (narrowband imaging) ne ICG fluorescence okulongoosa omutindo gw’okuzuula kookolo w’olubuto.

Fluorescence+ultrasound: Okuwandiika ICG ku bizimba by’olubuto nga kulungamizibwa endoscopic ultrasonography (EUS).

4. Okukiikirira abakola ebintu n’ebintu ebikolebwa

5. Okusoomoozebwa okw’ekikugu n’okugonjoola ebizibu

(1) Okukendeeza ku bubonero bwa fluorescence

Ekizibu: Ebbanga lya 5-ALA fluorescence liba ttono (essaawa nga 6).

Okugonjoola:

O Okugaba mu kulongoosa mu bitundutundu (nga okufuyira emirundi mingi nga balongoosa kookolo w’ekibumba).

(2) False positive/false negative

Ekizibu: Okuzimba oba ebitundu by’enkovu biyinza okusobya ku fluorescence.

Okugonjoola:

Okwekenenya okw’enjawulo (nga okwawula PpIX ku autofluorescence).

(3) Ebisale n’Okwettanirwa

Ekizibu: Bbeeyi y’enkola za fluorescent endoscopic systems eri waggulu (nga obukadde bwa Yuan 2 ku 5).

Obulagirizi bw’okumenyawo:

Okukyusakyusa mu maka (nga enkola ya Mindray ME8).

Endoscope eya fluorescent ekozesebwa omulundi gumu (nga Ambu aScope ICE).

6. Emitendera gy’enkulaakulana mu biseera eby’omu maaso

(1)Ekikebera ekipya ekitangalijja:Okuwandiika obubonero obukwata ku buziyiza obukwata ku kizimba (nga EGFR targeted probes).

(2) AI quantitative analysis:Okugabanya mu ngeri ey’obwengula ey’amaanyi g’ekitangaala (nga okukozesa pulogulaamu ya ProSense okwekenneenya obulwadde bw’ekizimba).

(3) Tekinologiya wa Nanofluorescence:Okuwandiika obubonero bwa Quantum dot (QDs) kisobozesa okukuba ebifaananyi ebikwatagana n’ebigendererwa ebingi.

(4) Okutambuza:Endoscope ekwata mu ngalo (nga ekozesebwa mu kukebera mu malwaliro agasookerwako).

mu bufunze

Tekinologiya w'okukuba ebifaananyi mu molekyu akyusa enkola y'okuzuula n'okujjanjaba ebizimba ng'ayita mu "precise labeling+real-time navigation":

Okuzuula: Omuwendo gw’okuzuula kookolo nga bukyali gweyongedde nnyo, ekikendeeza ku kulongoosa ebitundu by’omubiri ebiteetaagisa.

Obujjanjabi: Ekitundu ky’okulongoosa kibeera kituufu nnyo, ekikendeeza ku bulabe bw’okuddamu okulwala.

Ebiseera eby'omu maaso: Olw'enjawulo mu probes n'okugatta AI, kisuubirwa okufuuka ekintu eky'omutindo ku "intraoperative pathology".