Ubuvuzi bwa Endoscopi Ikoranabuhanga ryirabura (2) Ishusho ya Molecular Fluorescence (nka 5-ALA / ICG)

Intangiriro Yuzuye kuri 5-ALA / ICG Molecular Fluorescence Yerekana Amashusho muri Medical Endoscopy

Molecular fluorescence imashusho nubuhanga bwimpinduramatwara mubijyanye nubuvuzi bwa endoskopi yubuvuzi mumyaka yashize, bugera ku gihe nyacyo kandi nyacyo cyo gusuzuma no kuvura amashusho hifashishijwe uburyo bwihariye bwo guhuza ibimenyetso bya fluorescente (nka 5-ALA, ICG) nuduce twarwaye. Ibikurikira bitanga isesengura ryuzuye ryamahame ya tekiniki, gukoresha amavuriro, ibyiza byo kugereranya, ibicuruzwa bihagarariye, hamwe nibizaza.

1. Amahame ya tekiniki

(1) Uburyo bwibikorwa bya marike ya fluorescent

(2) Ibigize sisitemu yo gufata amashusho

Inkomoko yumucyo ushimishije: Uburebure bwihariye bwa LED cyangwa laser (nkumucyo wubururu bwubururu bwa 5-ALA).

Akayunguruzo keza: muyungurura urumuri rutambamirwa kandi rufata ibimenyetso bya fluorescence gusa.

Gutunganya amashusho: gutwikira ibimenyetso bya fluorescent hamwe namashusho yumucyo wera (nkigihe cyo guhuza igihe-cyerekana sisitemu ya PINPOINT).

2. Ibyiza byingenzi (vs gakondo yumucyo wera endoskopi)

3. Ibisabwa byo kwa muganga

(1) 5-ALA fluorescence endoscope

Kubaga Neuroshirurgie:

Kubaga Glioma resection: PpIX fluorescence yanditseho imbibi yibibyimba byongera igipimo cya 20% (niba byemewe gukoreshwa na GLIOLAN).

Urology:

O Gusuzuma kanseri y'uruhago: cystoskopi ya fluorescent (nka Karl Storz D-LIGHT C) igabanya umuvuduko wo kugaruka.

(2) ICG fluorescence endoscope

Kubaga Hepatobiliary:

Kubaga kanseri y'umwijima: kubaga neza neza kugumana ICG ahantu heza (nka Olympus VISERA ELITE II).

Kubaga amabere:

Sentinel lymph node biopsy: Gukurikirana ICG bisimbuza isotopi ya radio.

(3) Porogaramu nyinshi ihuriweho hamwe

Fluorescence + NBI: Olympus EVIS X1 ikomatanya amashusho yagutse hamwe na ICG fluorescence kugirango igabanye igipimo cyo gusuzuma kanseri yo mu gifu.

Fluorescence + ultrasound: ICG yanditseho ibibyimba bya pancreatic ibiyobowe na endoscopic ultrasonography (EUS).

4. Guhagararira abakora ibicuruzwa nibicuruzwa

5. Ibibazo bya tekiniki nibisubizo

(1) Ikimenyetso cya Fluorescence

Ikibazo: Igihe cya 5-ALA fluorescence ni gito (amasaha 6).

Igisubizo:

O Ubuyobozi bukora mubice (nka parufe nyinshi mugihe cyo kubaga kanseri y'uruhago).

(2) Ibinyoma byiza / bibi

Ikibazo: Gutwika cyangwa inkovu zishobora kwibeshya fluorescence.

Igisubizo:

Isesengura ryinshi (nko gutandukanya PpIX na autofluorescence).

(3) Igiciro no kumenyekana

Ikibazo: Igiciro cya sisitemu ya fluorescent endoscopique ni ndende (hafi miliyoni 2 kugeza kuri 5 Yuan).

Icyerekezo cy'iterambere:

Gusimburana murugo (nka Mindray ME8 sisitemu).

Ikoreshwa rya fluorescent endoscope (nka Ambu aScope ICE).

6. Iterambere ry'ejo hazaza

（1 pro Ubushakashatsi bushya bwa fluorescent: Tumor yihariye antibody fluorescent labels (nka EGFR igamije iperereza).

（2 analysis Isesengura ryinshi rya AI: Gutondekanya mu buryo bwikora ubukana bwa fluorescence (nko gukoresha software ya ProSense kugirango umenye ibibyimba bibi).

（3 technology Ikoranabuhanga rya Nanofluorescence: Akadomo ka Quantum (QDs) gatuma amashusho menshi agereranya amashusho.

（4） Portability: Handosld fluorescent endoscope (nko gukoreshwa mugupima mubitaro byibanze).

incamake

Tekinoroji ya molekuline ya fluorescence ihindura paradigima yo gusuzuma no kuvura ibibyimba binyuze "kuranga neza + kugihe nyacyo":

Gusuzuma: Igipimo cyo kumenya kanseri yo hambere cyiyongereye cyane, bigabanya biopsies bitari ngombwa.

Umuti: Amafaranga yo kubaga arasobanutse neza, agabanya ibyago byo kongera kubaho.

Kazoza: Hamwe no gutandukanya iperereza no guhuza AI, byitezwe ko bizaba igikoresho gisanzwe cya "intraoperative patology".