Isisombululo esiphazamisayo se-endoscopy yonyango kwi-diagnostic edibeneyo kunye nokunyangwa kwamathumba

1. Itekhnoloji yokuphumelela ukuxilongwa kwangoko kwamathumba

(1) I-Endoscopy ye-Molecular Imaging

Ukuphazamiseka kwezobuchwepheshe:

Iiprobe zefluorescent ezichongiweyo, ezifana ne-EGFR antibody Cy5.5 markers, zibophelela ngokukodwa kumhlaza wesisu sakwangoko (ubuntununtunu 92% vs endoscopy yokukhanya okumhlophe 58%).

I-Confocal Laser Microendoscopy (pCLE): Ukuqwalaselwa kwexesha langempela le-atypia yeselula kwi-1000x magnification, kunye nokuchaneka kokuxilonga kwe-95% kumhlaza we-Barrett's esophagus.

Imeko yeklinikhi:

I-National Cancer Centre yaseJapan isebenzise i-5-ALA eyenziwe yi-fluorescence ukuze ibone izilonda zomhlaza wesisu ekuqaleni kwe-1mm.

(2) Ixesha langempela le-AI lincedise inkqubo yokuxilonga

Ukuphunyezwa kobugcisa:

Ii-algorithms zokufunda nzulu ezifana ne-Cosmo AI zilebhelisha ngokuzenzekelayo iipolyps ngexesha le-colonoscopy, okukhokelela ekunyukeni kwe-27% kwinqanaba lokufumanisa i-adenoma (ADR).

I-Ultrasound endoscopy (EUS) idibaniswe ne-AI ukuhlula umngcipheko onobungozi we-pancreatic cysts (AUC 0.93 vs ingcali 0.82).

2, Isisombululo sotshintsho sonyango oluchanekileyo oluncinci

(1) Ukuphuculwa okuhlakaniphile kwe-endoscopic submucosal dissection (ESD)

Impumelelo yetekhnoloji:

I-3D ye-optical topology imaging: Inkqubo ye-Olympus EVIS X1 ibonisa i-real-time submucosal vascular course, ukunciphisa ukopha nge-70%.

I-Nanoknife incedise i-ESD: I-electroporation engenakuguqulelwa (IRE) yonyango lwe-intrinsic muscle layer infiltration izilonda, ukugcina ingqibelelo yesakhiwo esinzulu.

Idatha yokusebenza:

(2) I-Endoscopic ultrasound radiofrequency ablation (EUS-RFA) unyango oluphindwe kathathu

Ukudityaniswa kweTekhnoloji:

I-electrode ye-radiofrequency yangeniswa kwinaliti ye-19G yokuhlatywa, kwaye umhlaza we-pancreatic wachithwa phantsi kwesikhokelo se-EUS (izinga lolawulo lwendawo laliyi-73% ≤ 3cm tumor).

Ukudibanisa amaqamza e-nano (afana ne-paclitaxel perfluoropentane) ukufezekisa ukudityaniswa "kwechiza lokujonga unyango".

(3) I-fluorescence ekhokelwa yi-lymph node dissection

I-ICG kufuphi ne-infrared imaging:

I-Indocyanine eluhlaza yayijovwe kwiiyure ezingama-24 ngaphambi kokuhlinzwa, kwaye uvavanyo lwe-endoscopic lubonise i-sentinel lymph nodes kumdlavuza wesisu (izinga lokubona i-98%).

Idatha evela kwiYunivesithi yaseTokyo: I-lymph node dissection engekho yimfuneko yehle nge-40%, kwaye iziganeko ze-postoperative lymphedema zehla ukusuka kwi-25% ukuya kwi-3%.

3, Ukubeka iliso emva kokuhlinzwa kunye nesilumkiso sokuphindaphinda

(1) I-Endoscopy ye-Liquid Biopsy

Amagqabantshintshi obugcisa:

Yenza uhlalutyo lwe-ctDNA methylation kwiisampuli zebrashi ye-endoscopic (ezifana ne-SEPT9 gene) ukuqikelela umngcipheko wokuphindaphinda (AUC 0.89).

I-Microfluidic chip edityanisiweyo ye-endoscopy: Ukufunyaniswa kwexesha lokwenyani kweeseli zethumba elijikelezayo (CTCs) kulwelo lokuhlamba isisu.

(2) Inkqubo yekliphu yokumakisha enokufumaneka

Utshintsho lwetekhnoloji:

Iziqeshana ze-Magnesium alloy zazisetyenziselwa ukuphawula imida ye-tumor (efana ne-OTSC Pro), kwaye ukuthotywa kwenzeka kwiinyanga ze-6 emva kokuhlinzwa. Ulandelelwano lwe-CT alubonisanga izinto zakudala.

Xa kuthelekiswa neziqeshana ze-titanium: Ukuhambelana kwe-MRI kuphuculwe nge-100%.

I-4, iNkqubo yeNzululwazi eDityanisiweyo yokuQala

(1) I-Endoscopic laparoscopic hybrid surgery (AMANQAKU aHybrid)

Indibaniselwano yobuchwephesha:

Ukususwa kwee-tumor (ezifana nomhlaza we-rectal) ngendlela yendalo ye-endoscopic, edibene ne-laparoscopy ye-port enye ye-lymph node dissection.

Idatha evela kwiZiko leCancer yeYunivesithi yasePeking: Ixesha lotyando lincitshiswe yi-35%, izinga lokugcinwa kwe-anal liye landa kwi-92%.

(2) Iproton yonyango lwe-endoscopic navigation

Ukuphunyezwa kobugcisa:

Ukubekwa kwe-Endoscopic yeethegi zegolide + i-CT / MRI fusion, ukulandelwa okuchanekileyo kwe-esophageal cancer displacement kunye neproton beam (impazamo <1mm).

5. Izalathiso zobuchwepheshe bexesha elizayo

(1) DNA nanorobot endoscope:

"Irobhothi ye-origami" ephuhliswe yiYunivesithi yaseHarvard inokuthwala i-thrombin ukutywina ngokuchanekileyo imithambo yegazi yethumba.

(2) Uhlalutyo lwe-Metabolomics ngexesha lokwenyani:

I-Endoscopic edibeneyo ye-Raman spectroscopy isetyenziselwa ukuchonga iminwe yeminwe ye-tumor (efana ne-choline / i-creatine ratio) ngexesha lotyando.

(3) Uqikelelo lwempendulo ye-Immunotherapy:

I-PD-L1 i-fluorescent nanoprobes (inqanaba lovavanyo) lokuqikelela ukusebenza kwe-immunotherapy yomhlaza wesisu.

Itheyibhile yokuthelekisa iNzuzo yezonyango

Iingcebiso zendlela yokuphumeza

Iziko lokuhlola umhlaza kwangethuba: lixhotyiswe nge-endoscopy ye-molecular fluorescence kunye ne-AI encedisa inkqubo yokuxilonga.

Isibhedlele esikhethekileyo se-Tumor: ukwakhiwa kwe-EUS-RFA hybrid igumbi lokusebenza.

Ukuphumelela kophando: Ukuphuhlisa i-tumor probes ezithile (ezifana ne-Claudin18.2 ejoliswe kwi-fluorescence).

Ezi teknoloji ziqhuba ukuxilongwa kwethumba kunye nonyango kwixesha "lokuchaneka okuvaliweyo" ngokusebenzisa iimpumelelo ezintathu eziphambili: ukuxilongwa kwenqanaba lemolekyuli, unyango lwenqanaba le-millimeter, kunye nokubeka iliso okuguquguqukayo. Kulindeleke ukuba ngo-2030, i-70% yonyango lwasekhaya lwamathumba aqinileyo luya kukhokelwa yi-endoscopy.