Xalka qallafsan ee endoscopy caafimaad ee ogaanshaha isku dhafan iyo daaweynta burooyinka

1. Farsamada Breakthrough ee baaritaanka hore ee burooyinka

(1) Imaging molecular Endoscopy

Burburka tignoolajiyada:

Baarayaasha fluorescent ee la beegsaday, sida EGFR antibody Cy5.5 calamadaha, gaar ahaan waxay ku xidhan yihiin kansarka mindhicirka hore (dareenka 92% vs endoscopy iftiinka cad 58%).

Confocal Laser Microendoscopy (pCLE): Kormeerka dhabta ah ee atypia gacanta ee 1000x weynaynta, oo leh saxnaanta ogaanshaha ee 95% kansarka hunguriga Barrett.

Kiis caafimaad:

Xarunta Kansarka Qaranka ee Japan waxay isticmaashay 5-ALA fluorescence si ay u ogaato nabarrada kansarka caloosha ee hore <1mm.

(2) Waqtiga dhabta ah ee AI wuxuu caawiyay nidaamka ogaanshaha

Hirgelinta farsamada:

Algorithms-ka barashada qoto dheer sida Cosmo AI waxay si toos ah u calaamadiyaan polyps inta lagu jiro walamadka, taasoo keentay 27% korodhka heerka ogaanshaha adenoma (ADR).

Ultrasound endoscopy (EUS) oo ay weheliso AI si loo kala saaro khatarta xun ee finanka ganaca (AUC 0.93 vs khabiir 0.82).

2. Xalka kacaanka ee daawaynta ugu yar ee saxda ah

(1) Casriyeynta garaadka ee xuubka xuubka hoose ee endoscopic (ESD)

Horumarka tignoolajiyada:

Sawir-qaadista indhaha 3D: Nidaamka Olympus EVIS X1 wuxuu soo bandhigayaa koorsada xididdada xuubka-hoose ee-waqtiga-dhabta ah, hoos u dhigista dhiigga 70%.

Nanoknife waxay caawisay ESD: Electroporation (IRE) aan dib loo celin karin ee nabarada dhexda ee lakabka muruqa ee gudaha, ilaalinta sharafta qaabdhismeedka qoto dheer.

Xogta waxtarka leh:

(2) Endoscopic ultrasound radiofrequency ablation (EUS-RFA) daawaynta saddex jeer

Isdhexgalka farsamada:

Electrode-ka soo noqnoqda shucaaca ayaa lagu dhex galiyay irbadda dalool ee 19G, iyo kansarka ganaca ayaa laga saaray iyadoo ay hagayso EUS (heerka xakamaynta gudaha wuxuu ahaa 73% ≤ 3cm buro).

Isku darka xumbooyinka nano-ku raran ee daroogada (sida paclitaxel perfluoropentane) si loo gaaro is dhexgalka "daawaynta daawaynta".

(3) Kala-baxa qanjidhada qanjidhada ee fluorescence

ICG sawir-qaadis u dhow-infrared:

Cagaarka Indocyanine ayaa la duray 24 saacadood ka hor qaliinka, iyo baaritaanka endoscopic ayaa muujiyay qanjidhada qanjidhada ee kansarka caloosha (heerka ogaanshaha 98%).

Xogta laga helay Jaamacadda Tokyo: Kala-baxa qanjidhada aan daruuriga ahayn ayaa hoos u dhacay 40%, iyo dhacdooyinka qanjidhada qalliinka ka dib ayaa hoos uga dhacay 25% ilaa 3%.

3. La socoshada qalliinka kadib iyo digniinta soo noqoshada

(1) Biyo-qaadista dareeraha ah ee endoscopy

Tilmaamaha Farsamada:

Samee falanqaynta ctDNA methylation ee muunadaha burushka endoscopic (sida hidda-wadaha SEPT9) si loo saadaaliyo khatarta soo noqoshada (AUC 0.89).

Microfluidic chip-ka isku dhafan endoscopy: Ogaanshaha wakhtiga dhabta ah ee wareega wareega unugyada burooyinka (CTCs) ee dareeraha xuubka caloosha.

(2) Nadaamka clip sumadeynta la nuugi karo

Hal-abuurka farsamada:

Qaybaha daawaha ee Magnesium ayaa loo isticmaalay in lagu calaamadiyo xad-dhaafka buro (sida OTSC Pro), iyo xaalufku waxa uu dhacay 6 bilood qalliinka kadib. Dabagalka CT ma muujin wax farshaxan ah.

Marka la barbar dhigo cajaladaha titanium: waafaqid MRI waa la hagaajiyay 100%.

4,Barnaamijka hal-abuurka wadajirka ah ee kala duwan

(1) Qalliinka isku-dhafka ah ee endoscopic laparoscopic (XUSUUSIN isku-dhafan)

Isku dhafka farsamada:

Dib-u-soo-celinta burooyinka (sida kansarka malawadka) iyada oo loo marayo habka dabiiciga ah ee endoscopic, oo lagu daro hal deked laparoscopy oo loogu talagalay kala-baxa qanjidhada.

Xogta laga helay Xarunta Kansarka ee Jaamacadda Peking: Waqtiga qalliinka ayaa hoos loo dhigay 35%, heerka ilaalinta dabada ayaa kordhay 92%.

(2) daawaynta Proton endoscopic navigation

Hirgelinta farsamada:

Meelaynta Endoscopic ee calaamadaha dahabka + CT/MRI fusion, raadinta saxda ah ee barokaca kansarka hunguriga oo leh shucaac proton ah (qallad <1mm).

5. Tilmaamaha teknoolajiyada mustaqbalka

(1) DNA nanorobot endoscope:

"Robot-ka origami" ee ay samaysay Jaamacadda Harvard waxa uu qaadi karaa thrombin si uu si sax ah u xidho xididdada dhiigga ee burooyinka.

(2) Dheef-shiid kiimikaad-waqtiga-dhabta ah:

Endoscopic-ka isku-dhafan ee Raman spectroscopy waxaa loo isticmaalaa in lagu aqoonsado faraha dheef-shiid kiimikaadka burada (sida saamiga choline/creatine) inta lagu jiro qaliinka.

(3) Saadaasha jawaabta difaaca jirka:

PD-L1 fluorescent nanoprobes (marxaladda tijaabada) ee saadaalinta waxtarka kansarka gastric immunotherapy.

Shaxda Isbarbardhigga Faa'iidada Clinical

Talooyinka fulinta

Xarunta hore ee baaritaanka kansarka: ku qalabaysan endoscopy fluorescence molecular iyo habka ogaanshaha AI caawiyay.

Isbitaalka gaarka ah ee Tumor: dhismaha EUS-RFA qolka qalliinka isku-dhafka ah.

Horumarka cilmi baarista: Horumarinta baaritaanada gaarka ah ee buro (sida Claudin18.2 ee fluorescence lala beegsaday).

Farsamooyinkani waxay wadaan ogaanshaha burada iyo daawaynta xilliga "loop-xiran ee saxda ah" iyada oo loo marayo saddex guulood oo waaweyn: ogaanshaha heerka molecular, daaweynta heerka millimitirka hoose, iyo kormeer firfircoon. Waxa la filayaa in marka la gaadho 2030, 70% daawaynta maxaliga ah ee burooyinka adag lagu hogaamin doono endoscopy.