Igisubizo kibangamiye ubuvuzi bwa endoskopi mugupima hamwe no kuvura ibibyimba

1 technology Iterambere ryikoranabuhanga ryo gusuzuma hakiri kare ibibyimba

(1) Molecular Imaging Endoscopy

Ihungabana ry'ikoranabuhanga:

Intego za fluorescente zigamije, nka marike ya antibody ya EGFR Cy5.5, ihuza cyane na kanseri yo munda kare (sensibilité 92% vs urumuri rwera endoskopi 58%).

Confocal Laser Microendoscopy (pCLE): Kwitegereza igihe nyacyo kuri atypia selile mugihe cyo gukura kwa 1000x, hamwe no gusuzuma neza 95% kuri kanseri ya Esophagus ya Barrett.

Urubanza rwa Clinical:

Ikigo cy’igihugu cya kanseri cy’Ubuyapani cyakoresheje 5-ALA cyatewe na fluorescence kugirango hamenyekane ibikomere bya kanseri yo mu gifu hakiri kare <1mm.

(2) Igihe nyacyo AI yafashaga sisitemu yo gusuzuma

Gushyira mu bikorwa tekinike:

Kwiga byimbitse nka Cosmo AI ihita yandika polyps mugihe cya colonoskopi, bigatuma kwiyongera kwa 27% igipimo cyo kumenya adenoma (ADR).

Ultrasound endoscopi (EUS) ifatanije na AI kugirango itandukanye ibyago bibi bya cysts pancreatic cysts (AUC 0.93 vs umuhanga 0.82).

2 solution Igisubizo cyimpinduramatwara yo kuvura byimazeyo

(1) Kuzamura ubwenge bwubwenge bwa endoscopic submucosal (ESD)

Iterambere ry'ikoranabuhanga:

3D optique ya topologiya yerekana amashusho: Sisitemu ya Olympus EVIS X1 yerekana amasomo nyayo ya subucosal-nyayo, bigabanya kuva amaraso 70%.

Nanoknife yafashije ESD: Kuvura bidasubirwaho amashanyarazi (IRE) kuvura imitsi yimitsi yimitsi yinjira, bikomeza ubusugire bwimbitse.

Amakuru yingirakamaro:

(2) Endoscopic ultrasound radiofrequency ablation (EUS-RFA) ivura gatatu

Guhuza ikoranabuhanga:

Electrode ya radiofrequency yinjijwe mu rushinge rwa 19G, kandi kanseri yandura yanduye iyobowe na EUS (igipimo cy’ibanze cyari 73% ≤ 3cm ikibyimba).

Guhuza ibiyobyabwenge byuzuye nano bubbles (nka paclitaxel perfluoropentane) kugirango ugere ku guhuza "imiti ivura indorerezi".

(3) Fluorescence yayoboye lymph node gutandukana

ICG hafi-yerekana amashusho:

Icyatsi cya Indocyanine cyatewe inshuro 24 mbere yo kubagwa, kandi isuzuma rya endoskopique ryerekanye ko lymph node ya sentinel muri kanseri yo mu gifu (igipimo cya 98%).

Amakuru yaturutse muri kaminuza ya Tokiyo: Gutandukanya lymph node idakenewe yagabanutseho 40%, naho indwara ya lymphedema nyuma yo kubagwa yagabanutse kuva kuri 25% igera kuri 3%.

3 monitoring Gukurikirana nyuma yo gukurikiranwa no kuburira

(1) Amazi ya Biopsy Endoscopi

Ibyingenzi bya tekinike:

Kora isesengura rya methylation ya ctDNA kurugero rwa endoskopi ya brush (nka SEPT9 gene) kugirango umenye ibyago byo kongera kubaho (AUC 0.89).

Microfluidic chip ihuriweho na endoskopi: Igihe nyacyo cyo kumenya ingirabuzimafatizo zizunguruka (CTCs) mumazi yo munda.

(2) Sisitemu yerekana ibimenyetso bya clip

Guhanga udushya mu ikoranabuhanga:

Amashanyarazi ya magnesium yakoreshejwe mu kwerekana ibimenyetso by'ibibyimba (nka OTSC Pro), kandi kwangirika kwabaye nyuma y'amezi 6 nyuma yo kubagwa. CT ikurikirana yerekanye nta bihangano.

Ugereranije na clips ya titanium: guhuza MRI byazamutseho 100%.

4 Program Gahunda zitandukanye zo guhuriza hamwe udushya

(1) Kubaga Hybrid Endoscopic laparoscopic (ICYITONDERWA CYA Hybrid)

Gukomatanya tekinike:

Kurandura ibibyimba (nka kanseri y'inkondo y'umura) binyuze muburyo bwa endoskopique, bufatanije na port laparoscopi imwe yo gutandukanya lymph node.

Amakuru aturuka mu kigo cya kanseri ya kaminuza ya Peking: Igihe cyo kubaga cyagabanutseho 35%, igipimo cyo kubungabunga anal cyiyongereye kugera kuri 92%.

(2) Ubuvuzi bwa proton endoskopi

Gushyira mu bikorwa tekinike:

Gushyira endoskopique ya tagi ya zahabu + CT / MRI fusion, gukurikirana neza kwimura kanseri ya esofageal hamwe na proton beam (ikosa <1mm).

5 direction Icyerekezo cy'ikoranabuhanga kizaza

(1) ADN nanorobot endoscope:

"Imashini ya origami" yakozwe na kaminuza ya Harvard irashobora gutwara trombine kugirango ifunge neza imiyoboro y'amaraso y'ibibyimba.

(2) Metabolomics isesengura-nyaryo:

Endoscopic ihuriweho na Raman spectroscopy ikoreshwa mugutahura urutoki rwa metabolike yintoki (nka choline / creatine ratio) mugihe cyo kubagwa.

(3) Ubuhanuzi bwo gukingira indwara:

PD-L1 fluorescent nanoprobes (icyiciro cyubushakashatsi) kugirango hamenyekane ingaruka za immunoterapi ya kanseri yo mu gifu.

Imbonerahamwe yo Kugereranya Inyungu

Ibyifuzo byo gushyira mubikorwa

Ikigo cyambere cyo gusuzuma kanseri: gifite ibikoresho bya molekuline fluorescence endoscopy na AI bifasha sisitemu yo gusuzuma.

Tumor ibitaro kabuhariwe: kubaka icyumba cyo gukoreramo cya EUS-RFA.

Iterambere ryubushakashatsi: Gutezimbere ibibyimba byihariye (nka Claudin18.2 bigamije fluorescence).

Izi tekinoroji zitera gusuzuma no kuvura ibibyimba mugihe cya "precision closed-loop" binyuze mubintu bitatu byingenzi: gusuzuma urwego rwa molekile, kuvura urwego rwa milimetero, no gukurikirana imbaraga. Biteganijwe ko bitarenze 2030, 70% yubuvuzi bwibanze bwibibyimba bikomeye bizayoborwa na endoskopi.