Iteknoloji emnyama ye-endoscope yezonyango (8) i-imaging multispectral (efana ne-NBI/OCT)

Itekhnoloji ye-imaging ye-multispectral, ngokunxibelelana phakathi kokukhanya kwamaza ahlukeneyo kunye nezicubu, ifumana ulwazi olunzulu lwebhayoloji ngaphaya kwe-endoscopy yokukhanya okumhlophe kwendabuko, kwaye ibe ngumgangatho wegolide wokuxilongwa komhlaza kwangoko kunye nokuhamba ngokuchanekileyo kotyando. Oku kulandelayo kubonelela ngohlalutyo olucwangcisiweyo lobu bugcisa benguqu ukusuka kumacala asixhenxe:

1. Imigaqo yoBugcisa kunye neZiseko zoMzimba

Uthelekiso lweeMechanism zamehlo:

Udibaniso lwe-Multimodal:

Inkqubo edibeneyo ye-NBI-OCT (efana ne-Olympus EVIS X1): I-NBI ichonga iindawo ezikrokrisayo → i-OCT ivavanya ubunzulu bokungena

I-Fluorescence OCT (yaphuhliswa yi-MIT): Ukufakwa ileyibhile ye-Fluorescence yamathumba → i-OCT ichaza imida yokuhluza

2. Itekhnoloji engundoqo kunye ne-hardware innovation

Impumelelo yeTekhnoloji ye-NBI:

Itekhnoloji yokugquma itekhnoloji yokubona: Ibhandd emxinwa yokucoca ibhanti<30nm (i-Olympus patent)

Umlinganiselo wobude obubini: 415nm (i-capillary imaging)+540nm (umthambo ongaphantsi kwe-submucosal)

Ukuvela kwenkqubo ye-OCT:

I-domain ye-Frequency OCT: isantya sokuskena sinyuke ukusuka kwi-20kHz ukuya kwi-1.5MHz (efana ne-Thorlabs TEL320)

Uphononongo oluncinci: 1.8mm ububanzi obujikelezayo obujikelezayo (ilungele i-ERCP)

Uhlalutyo olongeziweyo lwe-AI:

Ukuhlelwa kwe-NBI VS (Inqanawa/uhlelo loMphezulu)

I-OCT glandular duct automatic segmentation algorithm (chaneko>93%)

3. Isicelo seklinikhi kunye nexabiso lokuxilonga

Iimpawu eziphambili ze-NBI:

Umhlaza we-Early esophageal (uhlelo lwe-IPCL): I-B1 yokufumanisa i-vascular sensitivity ifikelela kwi-92.7%

I-polyps ye-Colorectal (ukuhlelwa kwe-NICE): ukuhluka kwe-adenoma kunyuswe kwi-89%

Uncedo olulodwa lwe-OCT:

I-Cholangiocarcinoma: Ukuchongwa kokutshatyalaliswa kwe-hierarchical yodonga lwe-bile duct <1mm

Barrett's esophagus: umlinganiselo we-atypical hyperplasia ubukhulu (chaneka 10 μ m)

Idatha yenzuzo yonyango:

Iziko leSizwe loMhlaza laseJapan: I-NBI yonyusa izinga lokufunyanwa komhlaza wesisu ukusuka kwi-68% ukuya kwi-87%

Isikolo sezoNyango saseHarvard: Inqanaba lotyando elikhokelwa yi-OCT ye-ESD lehla laya kutsho kwi-2.3%.

4. Ukumela abavelisi kunye neeparamitha zenkqubo

5. Imingeni yobugcisa kunye nezisombululo

Unyino lwe-NBI:

Ijiko lokufunda lingumnqantsa:

Isisombululo: Ukuchwetheza okwenyani kwe-AI (okufana ne-ENDO-AID)

Uphononongo oluphosiweyo lwezilonda ezinzulu:

Umlinganiselo wokunqanda: i-Joint EUS (Endoscopic Ultrasound)

OCT umqobo:

I-artifact eshukumayo:

Ukuphumelela: I-Holographic Optical Coherence Tomography (HOCT)

Uluhlu lwemifanekiso encinci:

Utshintsho: I-Panoramic OCT (efana nesetyhula ephuhliswe yi-MIT)

6. Inkqubela yophando yamva nje

2024 Ukuphumelela okuPhambili:

Isisombululo esiphezulu OCT: I-Caltech yophula umda we-diffraction (4 μ m → 1 μ m) ngokusekelwe kufundo olunzulu

I-Molecular spectrum navigation: IYunivesithi yaseHeidelberg iqonda iRaman NBI-OCT iindlela ezintathu zokudityaniswa

I-NBI eNxitywayo: I-Capsule NBI iphuhliswe ngu-Stanford (iNdalo ye-BME 2023)

Ulingo lwezonyango:

Isifundo se-PROSPECT: Ukuqikelelwa kwe-OCT yomhlaza wesisu se-lymph node metastasis (AUC 0.91)

I-CONFOCAL-II: I-NBI + AI inciphisa ii-biopsies ezingafunekiyo nge-43%

7. IiNdlela zoPhuhliso lwexesha elizayo

Ukudityaniswa kweTekhnoloji:

Ithala leencwadi elikrelekrele leSpectral: Ipixel nganye iqulethe i-400-1000nm yedatha epheleleyo

Ukuleyibhelishwa kwamachaphaza e-Quantum: CdSe/ZnS amachaphaza omthamo aphucula umahluko othile ekujoliswe kuwo

Ulwandiso lwesicelo:

Ukuhamba ngotyando: Ixesha langempela lokujongwa kwe-OCT yokugcinwa kwemithambo-luvo (utyando lomhlaza wesibeleko)

Uvavanyo lwe-Pharmacological: Ubungakanani be-NBI ye-mucosal angiogenesis (ukubeka iliso kunyango lwe-Crohn's disease)

uqikelelo lwemarike:

Ngo-2026, imakethi ye-NBI yehlabathi iya kufikelela kwi-$ 1.2B (CAGR 11.7%).

Izinga lokungena kwe-OCT kwintsimi ye-gallbladder kunye ne-pancreas iya kudlula i-30%

Isishwankathelo kunye nembonakalo

Ukucinga ngezinto ezininzi kuqhuba i-endoscopy kwixesha le "optical biopsy":

I-NBI: Ukuba ngumgangatho 'we-Optical Staining' wokuHlolwa koMhlaza kwangethuba

I-OCT: Ukuphuhla kwisixhobo senqanaba le-in vivo pathology

Eyona njongo igqibeleleyo: Phumelela ngokupheleleyo "i-digital pathology" kwaye utshintshe ngokupheleleyo i-paradigm yokuxilongwa kwezicubu.