Ukadaulo wakuda wa endoscope wakuda (8) kujambula kwamitundu yosiyanasiyana (monga NBI/OCT)

Ukadaulo woyerekeza wamitundu yosiyanasiyana, kudzera mu kuyanjana pakati pa kuwala kwa mafunde osiyanasiyana ndi minyewa, imapeza chidziwitso chakuya chachilengedwe kuposa endoscopy yoyera yoyera, ndipo yakhala muyeso wagolide pakuzindikira khansa yoyambirira komanso kuyendetsa bwino opaleshoni. Zotsatirazi zikupereka kusanthula kwadongosolo kwaukadaulo wosinthikawu kuchokera ku miyeso isanu ndi iwiri:

1. Mfundo Zaumisiri ndi Zofunikira Zathupi

Kuyerekeza kwa Optical Mechanisms:

Kuphatikizika kwa Multimodal:

Njira yophatikizira ya NBI-OCT (monga Olympus EVIS X1): NBI imazindikira madera okayikitsa → OCT imayesa kuya kwa kulowa.

Fluorescence OCT (yopangidwa ndi MIT): Fluorescence kulemba zotupa → OCT kufotokoza malire a resection

2. Ukadaulo wapakatikati ndi luso la hardware

Kupambana kwaukadaulo wa NBI:

Ukadaulo wokutira wokutira: Bandi yopapatiza yosefera <30nm (patent ya Olympus)

Mafunde apawiri: 415nm (kujambula kwa capillary) + 540nm (mtsempha wa submucosal)

Kusintha kwadongosolo la OCT:

Kuthamanga kwafupipafupi OCT: Kuthamanga kwa scanning kunakwera kuchokera ku 20kHz kufika ku 1.5MHz (monga Thorlabs TEL320)

Kafufuzidwe kakang'ono: kafukufuku wozungulira wa 1.8mm (woyenera ERCP)

Kuwunika kowonjezereka kwa AI:

Gulu la NBI VS (Zotengera / Pamwamba)

OCT glandular duct automatic segmentation algorithm (kulondola> 93%)

3. Kugwiritsa ntchito chipatala ndi kufunika kwa matenda

Zizindikiro zazikulu za NBI:

Khansara yoyambirira ya esophageal (IPCL classification): Kuzindikira kwa mitsempha ya B1 kumafika 92.7%

Ma polyps amtundu (NICE classification): kusiyanitsa kwa adenoma kumawonjezeka mpaka 89%

Ubwino wapadera wa OCT:

Cholangiocarcinoma: Chizindikiritso cha kuwonongedwa kwakukulu kwa khoma la bile duct <1mm

Barrett's esophagus: muyeso wa makulidwe atypical hyperplasia (kulondola 10 μm)

Zambiri zazachipatala:

National Cancer Center ku Japan: NBI imawonjezera kuchuluka kwa khansa ya m'mimba kuyambira 68% mpaka 87%

Harvard Medical School: OCT motsogozedwa ndi ESD maginito opangira opaleshoni atsika mpaka 2.3%

4. Kuyimira opanga ndi magawo a dongosolo

5. Mavuto aukadaulo ndi mayankho

Zochepa za NBI:

Njira yophunzirira ndiyokwera:

Yankho: Kulemba kwanthawi yeniyeni kwa AI (monga ENDO-AID)

Kuzindikira kopanda zotupa zakuya:

Countermeasure: Joint EUS (Endoscopic Ultrasound)

Zovuta za OCT:

Zoyenda:

Kupambana: Holographic Optical Coherence Tomography (HOCT)

Chigawo chaching'ono chojambula:

Innovation: Panoramic OCT (monga kusanthula kozungulira kopangidwa ndi MIT)

6. Kafukufuku waposachedwa

Kupambana Kwambiri kwa 2024:

Kusintha kwakukulu OCT: Caltech imadutsa malire a diffraction (4 μ m → 1 μ m) kutengera kuphunzira mozama

Navigation ya ma molekyulu: University of Heidelberg imazindikira Raman NBI-OCT njira zitatu zophatikizira

NBI Yovala: Capsule NBI Yopangidwa ndi Stanford (Nature BME 2023)

Mayesero azachipatala:

Phunziro la PROSPECT: Kuneneratu kwa OCT kwa khansa ya m'mimba ya lymph node metastasis (AUC 0.91)

CONFOCAL-II: NBI + AI imachepetsa ma biopsies osafunikira ndi 43%

7. Zochitika Zachitukuko Zamtsogolo

Kuphatikiza kwaukadaulo:

Intelligent Spectral Library: Pixel iliyonse imakhala ndi data ya 400-1000nm yonse

Kulemba madontho a Quantum: Madontho amtundu wa CdSe/ZnS amawonjezera kusiyanitsa komwe mukufuna

Ntchito yowonjezera:

Kuyenda Opaleshoni: Kuwunika kwanthawi yeniyeni kwa OCT pakusunga mitsempha (opaleshoni ya khansa ya prostate)

Pharmacological evaluation: NBI quantification of mucosal angiogenesis (Crohn's disease treatment monitoring)

kulosera zamsika:

Pofika 2026, msika wapadziko lonse wa NBI ufika $1.2B (CAGR 11.7%).

Kulowa kwa OCT m'munda wa ndulu ndi kapamba kudzapitilira 30%

Chidule ndi mawonekedwe

Kujambula kosiyanasiyana kumayendetsa endoscopy mu nthawi ya "optical biopsy":

NBI: Kukhala Muyezo wa 'Optical Staining' pakuwunika koyambirira kwa khansa

OCT: Kupanga chida cha mu vivo pathology level

Cholinga chachikulu: Kukwaniritsa mawonekedwe a "digito pathology" ndikusintha kwathunthu mawonekedwe a matenda a minofu.