Tekinologiya w’omuddugavu ow’obujjanjabi (medical endoscope black technology) (8) okukuba ebifaananyi mu ngeri ey’enjawulo (nga NBI/OCT) .

Tekinologiya w’okukuba ebifaananyi mu ngeri ey’enjawulo (multispectral imaging technology), okuyita mu nkolagana wakati w’ekitangaala eky’obuwanvu bw’amayengo obw’enjawulo n’ebitundu by’omubiri, afuna amawulire amazito agakwata ku biramu okusukka endoscopy y’ekitangaala ekyeru eky’ennono, era afuuse omutindo gwa zaabu ogw’okuzuula kookolo nga bukyali n’okutambulira mu ngeri entuufu ey’okulongoosa. Wammanga biwa okwekenneenya okutegekeddwa okwa tekinologiya ono akyusa okuva mu bitundu musanvu:

1. Emisingi gy’Ebyekikugu n’Emisingi gy’Eby’Omubiri

Okugerageranya Enkola z’amaaso:

Okuyungibwa mu ngeri ez’enjawulo:

Enkola ya NBI-OCT egatta (nga Olympus EVIS X1): NBI ezuula ebitundu ebiteeberezebwa → OCT yeetegereza obuziba bw’okuyingira

Fluorescence OCT (ekoleddwa MIT): Okuwandiika ebizimba mu fluorescence → OCT okunnyonnyola ensalo z’okusalako

2. Okuyiiya tekinologiya omukulu ne hardware

Okumenyawo Tekinologiya wa NBI:

Tekinologiya w’okusiiga amaaso: Narrow band filter bandwidth<30nm (Olympus patent)

Omugerageranyo gw’obuwanvu bw’amayengo abiri: 415nm (okukuba ebifaananyi mu misuwa)+540nm (omusuwa ogw’omugongo)

Enkulaakulana y’enkola ya OCT:

Frequency domain OCT: sipiidi ya sikaani yeeyongedde okuva ku 20kHz okutuuka ku 1.5MHz (nga Thorlabs TEL320)

Miniature probe: 1.8mm diameter ekipima ekikyukakyuka (ekisaanira ERCP)

Okwekenenya okunywezeddwa mu AI:

NBI VS classification (Ebibinja by’Emmeeri/Eby’okungulu) .

OCT glandular duct enkola y’okugabanya mu ngeri ey’otoma (obutuufu>93%) .

3. Okukozesa mu bujjanjabi n’omugaso gw’okuzuula

Ebikulu ebiraga nti NBI:

Kookolo w’omumwa gwa nnabaana nga bukyali (IPCL classification): Obuwulize bw’okuzuula emisuwa gya B1 butuuka ku bitundu 92.7% .

Colorectal polyps (NICE classification): enjawulo mu adenoma specificity yeeyongera okutuuka ku 89% .

Ebirungi eby’enjawulo ebiri mu OCT:

Cholangiocarcinoma: Okuzuula okusaanyaawo mu nsengeka y’ekisenge ky’omukutu gw’omusaayi<1mm

Barrett’s esophagus: okupima obuwanvu bwa atypical hyperplasia (obutuufu 10 μ m) .

Ebikwata ku migaso gy’obujjanjabi:

National Cancer Center of Japan: NBI eyongedde omuwendo gw’okuzuula kookolo w’olubuto nga bukyali okuva ku bitundu 68% okutuuka ku bitundu 87%

Harvard Medical School: OCT guided ESD surgical margin omuwendo gw’abalina obulwadde buno gukendedde okutuuka ku bitundu 2.3%

4. Okukiikirira abakola ebintu n’ebipimo by’enkola

5. Okusoomoozebwa okw’ekikugu n’okugonjoola ebizibu

Ebikoma ku NBI:

Enkola y’okuyiga eri waggulu:

Ekigonjoolwa: Okuwandiika mu kiseera ekituufu ekya AI (nga ENDO-AID) .

Okusubwa okuzuula ebiwundu ebizito:

Okuziyiza: EUS y’ekiwanga (Endoscopic Ultrasound) .

OCT ekizibu:

Ekintu ekikolebwa mu kutambula:

Okumenyawo: Okukebera okukwatagana kw’amaaso (Holographic Optical Coherence Tomography) (HOCT) .

Obufo obutono obw’okukuba ebifaananyi:

Obuyiiya: Panoramic OCT (nga circular scan eyakolebwa MIT)

6. Enkulaakulana mu kunoonyereza okusembyeyo

2024 Okumenyawo Ensalo:

Super resolution OCT: Caltech emenya ekkomo lya diffraction (4 μ m → 1 μ m) nga yesigamye ku kuyiga okw’obuziba

Okutambulira mu molekyu: Yunivasite y’e Heidelberg etegeera Raman NBI-OCT three mode fusion

NBI eyambalibwa: NBI ya Capsule Ekoleddwa Stanford (Nature BME 2023)

Okugezesebwa mu malwaliro:

Okunoonyereza ku PROSPECT: OCT okulagula ku kookolo w’olubuto lymph node metastasis (AUC 0.91)

CONFOCAL-II: NBI+AI ekendeeza ku biopsies eziteetaagisa ne 43%

7. Emitendera gy’enkulaakulana mu biseera eby’omu maaso

Okugatta tekinologiya:

Intelligent Spectral Library: Buli pixel erimu data ya spectrum enzijuvu eya 400-1000nm

Okuwandiika ennukuta za quantum: Ennyiriri za quantum eza CdSe/ZnS zongera ku njawulo y’ekigendererwa ekigere

Okwongera ku nkola:

Okulongoosa okutambulira: Okulondoola OCT mu kiseera ekituufu okusobola okukuuma obusimu (okulongoosa kookolo w’enseke)

Okukebera eddagala: NBI quantification of mucosal angiogenesis (okulondoola obujjanjabi bw’obulwadde bwa Crohn)

okulagula akatale:

Mu mwaka gwa 2026, akatale ka NBI mu nsi yonna kagenda kutuuka ku $1.2B (CAGR 11.7%)

Omuwendo gw’okuyingira kwa OCT mu kisaawe ky’ennywanto n’olubuto gujja kusukka ebitundu 30% .

Mu bufunze n’endowooza

Okukuba ebifaananyi mu ngeri ey'enjawulo (multispectral imaging) kwe kuvuga endoscopy mu mulembe gwa "optical biopsy":

NBI: Okufuuka omutindo gwa ‘Optical Staining’ ogw’okukebera kookolo nga bukyali

OCT: Okukulaakulanya okufuuka ekintu eky’omutendera gw’endwadde mu mubiri (in vivo pathology level tool).

Ekigendererwa ekisembayo: Okutuuka ku "digital pathology" mu bujjuvu n'okukyusa ddala enkola y'okuzuula ebitundu by'omubiri